The IANO is coordinated by an elected National Executive Committee. This committee is comprised of 14 voluntary representatives: president, secretary and treasurer, regional networks representatives and Special Interest Groups (SIGs) representatives and a early career cancer nurse representative, as well as a representative from academia, paediatrics, and a service provider*. The committee members facilitate the objectives of the association. The NEC is supported by a secretariat.

*Service provider: Irish Cancer Society

Each SIG and Network co-ordinate events at a local level throughout the year in addition to National events held by the IANO.